In our lab we are interested in bridging advances in instrumentation and nanofabrication with insights into biophysical phenomena at the smallest scale. We focus on developing ultrasensitive nanoelectromechanical systems (NEMS) to study fundamental questions and tackle challenges in nanobiology, including molecular diagnostics and size-selective biomolecular transport across cell membranes. Our current research is focused on two broad themes:
Acousto-photonic nanofluidics - We are building novel single-molecule analysis platforms by combining advances in 2D material nanophotonics, nanopore technologies and acoustofluidics. We are particularly interested in understanding acoustic-structure effects and light-matter interactions at the nanoscale for single-molecule confinement, manipulation and detection.
DNA origami nanoactuators - Using cutting-edge techniques such as DNA origami self-assembly, acoustic tweezers and fast-scan AFM imaging, we study the mechanics and dynamics of mechanically-adaptable nanopores for on-demand delivery of diagnostically relevant macromolecules in cells.
CanevaLab May 2022